Xenoestrogens cause Breast Cysts (by Elizabeth Smith, MD)
Breast Cysts provoked by Xenoestrogens are found in everyday synthetic artificial materials. These materials were previously thought to be inert.
How to avoid Xenoestrogens
Xeno literally means foreign. So xenoestrogens means foreign estrogens. Some of the 100,000 registered chemicals for use in the world have hormonal effects in addition to toxic and carcinogenic effects. Also the synergistic effects are known to occur but also are largely exactly unknown. The field of xenohormones is new, and only been in existence since about 1991. Xenoestrogens are thought to cause preccious puberty (premature puberty), breast cancer and breast cysts. See the Breast Cancer Fund paper on Environmental Estrogens Here.
Critics have proclaimed that these chemicals are for the most part “weak”. The body’s hormones are at levels of parts per trillion. However, many of the chemicals that affect the hormone systems are routinely found in the serum after sauna at parts per billion. In other words, these chemicals that affect the hormone systems of the human body occur at 100 to 1000 times greater concentration than that of the normal human hormones. One researcher demonstrated that two “weak” estrogens may act synergistically to give a strong estrogen response. Some of these Xenoestrogens like DDE (a metabolite of DDT) may persist in the body fat for decades. Many of these mimicking hormones were previously thought to occur in pesticides. However, many of the newly discovered xenoestrogens are found in every day previously thought to be inert materials. Yes, it is highly probable that environmental estrogens, xenoestrogens are causing breast cysts.
Some of the following is information taken from Our Stolen Future by Theo Colborn:
A study published in the Proceedings of the Society of Experimental Biology and Medicine in 1950 by two Syracuse University Zoologists Lindeman and Burlington described how doses of DDT prevented young roosters from developing normally. They injected DDT into roosters by injecting the pesticide into forty young roosters for a period of 2 to 3 months. The daily doses of DDT did not kill the roosters or even make them sick. It made them look weird; they looked like hens. The birds testicles were only 18% of normal size. Their combs and wattles remained stunted and pale. The roosters were chemically castrated.
Micheal Fry, a wild life toxicologist, at the University of California at Davis injected eggsfrom western and California gull colonies with DDT and a breakdown product of DDT, DDE, and methoxychlor (another synthetic pesticide known to bind to estrogen receptors). He found the feminization of the male’s reproductive tracts. Typical female cells were found in the testicles, and in cases of higher doses, the presence of an oviduct, the egg-laying canal normally found only in females. Despite all this internal disruption, the chick looked completely normal.
“The roosters were chemically castrated by DDT.”
DDT was found to bind to the estrogen receptor sites. It is now considered one of the classic xenoestrogens.
DDT was banned in the United States. However, world wide production of DDT has never been higher. In fact, DDT is manufactured in the United States and shipped to third world countries. DDT is metabolized to DDE in the human body within a few months. DDE then may last in the human body for several decades. However, some medical doctors occasionally find DDT in the serum routinely following intensive sauna. So where is this new exposure to DDT coming from? The United States ships DDT to third world countries that spray it on vegetables and fruits. This agricultural produce is shipped to United States supermarkets where Americans consume it. In 1991, the United States exported 96 tons of DDT.
Another source may come from your living area. If your house is near or built upon old agricultural land, DDT will persist in the soil for several centuries.
Plastics, Spermacide, Detergent, and Personal Care Products
At Tufts Medical School in Boston in 1987, Soto and Sonnenschein serendipitously discovered that plastic test tubes thought to be inert contained a chemical that stimulated breast cancer cells to grow and proliferate wildly. They were experimenting with malignant breast cancer cells that were sensitive to estrogen. When exposed to estrogen the cells would grow and multiply, and when isolated from estrogen, the cells would stop multiplying.
During the course of their experiments, they found that the test tube manufacturer changed the formulation of the plastic test tubes that they were using. The manufacturer had used p-nonylphenol one of the family of synthetic chemicals called alkylphenols to make these plastics more stable and less breakable. Manufacturers routinely add nonlyphenols to polystyrene and polyvinyl chloride (PVC). These new plastic test tubes caused their estrogen sensitive breast cancer cells to proliferate, multiply and grow. Thus, they concluded that p-nonylphenol acted like an estrogen.
One study showed that the food processing industry and packaging industry used PVC’s that contained nonlyphenols. Another reported contamination of water that had passed through PVC tubing. Even a compound found in contraceptive creams nonoxynol-9 breaks down inside the animal’s body to produce nonylphenol. Breakdown of chemicals such as those found in industrial detergents, pesticides, and personal care products give rise to nonylphenol. Global production of alkylphenols polyethoxylate was 600 million pounds in 1990. Although the products purchased by the consumer are not themselves estrogenic; studies have found that bacteria in the animal’s bodies, in the environment, or in sewage treatment plants degrade these alkylphenol polyethoxylates, creating nonylphenol and other xenoestrogens.
Plastic Drinking Bottles and Plastics used with food
In 1993, at Stanford University School of Medicine, Dave Feldman, professor of medicine was experimenting with a yeast estrogen protein that binds to estrogen. They found that the polycarbonate bottles used to hold drinking water contained bisphenol-A. They used the polycarbonate lab flasks to sterilize the water used in their experiments. Bispheol-A- nicely bound to the estrogen protein found in the yeast. This polycarbonate plastic is routinely used for the giant jugs used in shipping water.
The manufacturer was aware that the bottles would leach particularly if exposed to high temperatures and caustic cleaners and so developed a washing regimen that they thought would solve the problem. However, the researchers discovered that the manufacturer could not detect samples sent from their lab. Samples that were causing proliferation of estrogen responsive breast cancer cells. This proved to be a detection limit in the manufacturer’s lab equipment. The Stanford team found that 2-5 parts per billion of bisphenol-A was enough to cause the breast cancer to proliferate.
Professor Feldman noted that though bisphenol-A is 2000X less potent than estrogen, “it still has activity in the parts per billion range.”
One Dartmouth University Study showed that plastic wrap heated in a microwave oven with vegetable oil had 500,000 times the minimum amount of xenoestrogens needed to stimulate breast cancer cells to grow in the test tube.
Detergent Breakdown Products
John Sumpter a biologist from Brunel University in Uxbridge began to study sexually confused fish reported from anglers fishing in English rivers. Many fish caught in the lagoons and pools just below the discharge from sewage plants looked quite bizarre. Even experienced fisherman could not tell if a fish was male or female. The fish showed male and female characteristics at the same time. They were perfect examples of intersex where an individual is stranded between both sexes.
Sumpter used a marker that helped identify female fish. Normally in females a special egg protein is made called vitellogenin, in response to estrogen from the ovaries. On the estrogen signal from the ovaries, the liver produces vitellogenin and the protein is incorporated into the eggs. Since the response is dependent on estrogen, vitellogenin levels found in male fish would be a good indication of estrogen exposure.
Caged fish raised in captivity and then kept in the contaminated pools made 1000X to 100,000X more vitellogenin than control trout kept in clean water.
15 sites were sampled with soaring vitellogenin levels. It was a national problem. Alkylphenol levels from detergent breakdown products are high on the suspect list. However, Sumpter suspects that it is the synergistic qualities of several xenoestrogens acting together.
In 2004, 42% of male bass in the potomac river near Washington DC were found to be producing eggs. Researchers highly suspect hormone disrupting chemicals in the river are causing male bass to be sort of female. This also mirrors a similar study that found feminized male Colorado fish called White Suckers in the river below a sewage treatment plant. As of 2004, little is done to test for these chemicals — either in river water or in drinking water. The U.S. Environmental Protection Agency has not set standards, saying more research is needed to determine which contaminants are harmful and what levels are unsafe.
Two Spanish Scientists at the University of Granada decided to investigate the plastic coatings that manufacturers use to line the metal cans. The coating is added to avoid the metallic taste of metal in the food from the cans. These linings are present in about 85% of the cans. Fatima Olea and Nicolas Olea an M.D. specializing in endocrine cancers worked with Soto and Sonnenschein. In a study analyzing twenty brands of canned foods purchased in the United States and in Spain, they discovered bisphenol-A, the same chemical that the Stanford researchers discovered in about half of the canned food up to levels of 80 parts per billion. This is 27 times greater concentration of bisphenol-A needed to cause the breast cancer cells to proliferate in the Stanford Study.
Commercially raised Beef, Chicken and Pork
Commercially raised livestock are routinely given xenoestrogens to fatten them up and cause them to retain water. This results in greater profits for the farmer. It is an effective, cheap, quick way to fatten them up. In the 1970’s and 1980’s there was an epidemic in Puerto Rico of early puberty in girls as young as a year old and even young boys who developed breasts caused by meat and dairy products containing high levels of estrogen. In the United States, the use of estrogen compounds is now slightly better regulated, but it is still very much used and abused.
“Young boys developed breasts.”
John Lee, M.D.
DES (diethylstilbesterol), a type of synthetic estrogen, was the first hormone to be used by the meat industry to fatten up livestock until it was discovered that it causes cancer even in extremely minute amounts.
Birth Control Pills
Birth Control Pills contain a synthetic estrogen and a synthetic progesterone to force the body to cycle in a normal manner even though conception may have occurred and different hormones levels are supposed to occur. Is it really nice to fool mother nature? Adding extra estrogen to a women’s body exacerbates breast cysts.
Why not use a simpler method of birth control such as condoms? Use one that does not use a spermicide such as nonoxynol-9. Researchers found that once nonoxynol-9 gets into a rats body it breaks down into nonylphenol – a known xenoestrogen.
Preservative Methyl Paraben in Skin Lotions and Gels
For many years, parabens were considered among those preservatives with low systemic toxicity, primarily causing allergic reactions. However, as we have become aware that some synthetic chemicals mimic the female hormone estrogen, our understanding of the toxic effects of both synthetic and natural substances has changed. Now, John Sumpter from the Department of Biology & Biochemistry, Brunel University, Uxbridge, Middlesex, have found that alkyl hydroxy benzoate preservatives (namely methyl-, ethyl-, propyl-, and butylparaben) are weakly estrogenic. In an estrogen receptor-binding assay, butylparaben was able to compete with the female hormone estradiol for binding to estrogen receptors with an affinity approximately 5 orders of magnitude lower than that of diethylstilbestrol (a highly carcinogenic synthetic estrogen), and between 1 and 2 orders of magnitude less than nonylphenol (an estrogenic synthetic industrial chemical).
Although it is reassuring to note that when administered orally, the parabens were inactive, subcutaneous administration of butylparaben produced a positive estrogenic response on uterine tissues. Although approximately 100,000 times less potent than17 beta-estradiol, greater exposure to the parabens may compensate for their lower potency. The researchers conclude that, “Given their use in a wide range of commercially available topical preparations, it is suggested that the safety in use of these chemicals should be reassessed . . .”
The European Union has asked the European Cosmetics and Toiletry industry about these new findings and the implication for breast cancer. These preservatives are found in the vast majority of skin an body lotions, even in natural progesterone creams. Generally, for the sterol hormones, taken orally the hormones are 90% first pass metabolized by the liver. Thus, taken orally only 10% reaches the body. In contrast, anything absorbed by the skin is directly absorbed. In other words, anything absorbed through the skin may be as high as 10 times the concentration of an oral dose.
Unfortunately, some natural progesterone creams were found to contain methyl and propyl parabens as a preservative.
Shampoos that Purposely Contain Very High Amounts of Estrogen
African Americans favored shampoos with clinically active high doses of estrogen. They also used them on their children. In 1998 Tiwary, now retired, published a study of four girls – including a 14-month-old – who developed breasts or pubic hair months after beginning to use such products. The symptoms started to disappear when they stopped using them. The year before, he published a study showing that some of the products used by his patients contained up to one milligram (1 mg) of estradiol per one ounce of shampoo. By comparison a normal adult topical skin dose for estradiol is 0.02-0.05 mg/day. This means that one ounce of shampoo contains 50 times the daily ADULT dose of estradiol. A small handful of this shampoo on your child every day may give her OR HIM breasts! See the article here.
Tyrone B. Hayes of the University of California at Berkeley found that atrazine, the most commonly used weed killer in North America, affected frogs at doses as small as 0.1 part per billion. As the amount of atrazine increased, as many as 20 percent of frogs exposed during their early development produced multiple sex organs or had both male and female organs. Many had small, feminized larynxes. (feminized frogs http://www.nobreastcyst.com/frog.html)
Plastic IV Bags
The United States FDA warns that prolonged fluid exposure in IV bags may affect testicle development in young boys. The chemical, called DEHP, can leach from the plastic into certain liquids, especially fat-containing ones like blood. Studies of young animals show the chemical can affect testicle development and production of normal sperm. Some companies already label that their products contain phthalates (DHEP), and the FDA soon will issue a recommendation, not a requirement, that more companies do so.
“FDA’s public health notification falls far short of what is needed to protect patients,” said Charlotte Brody of Health Care Without Harm, a group working to reduce the amount of phthalates, the family of chemicals that includes DEHP, in a variety of products, from plastic toys to cosmetics. (FDA article here http://www.nobreastcyst.com/fda.html)
5 Out of 6 Chemicals Used to block UV in Sunscreen are Estrogenic
Margaret Schlumpf and her colleagues (Institute of Pharmacology and Toxicology, University of Zurich, Switzerland) have found that many widely-used sunscreen chemicals mimic the effects of estrogen and trigger developmental abnormalities in rats. (Schlumpf , Margaret; Beata Cotton, Marianne Conscience, Vreni Haller, Beate Steinmann, Walter Lichtensteiger. In vitro and in vivo estrogenicity of UV screens. Environmental Health Perspectives Vol. 109 (March 2001) pp 239-244) Her group tested six common chemicals that are used in sunscreens, lipsticks and facial cosmetics. Five of the six tested chemicals (benzophenone-3, homosalate, 4-methyl-benzylidene camphor (4-MBC), octyl-methoxycinnamate and octyl-dimethyl-PABA) behaved like strong estrogen in lab tests and caused cancer cells to grow more rapidly. Only one chemical – a UVA protector called butyl-methoxydibenzoylmethane (B-MDM) – showed no activity. Uterine growth and endometriosis :One very common sunscreen chemical, 4-MBC, was mixed with olive oil and applied to rat skin. This caused a doubling of the rate of uterine growth well before puberty. “That was scary, because we used concentrations that are in the range allowed in sunscreens,” said Schlumpf. Three of the six caused developmental abnormalities in animals. The major cause of sterility in women in the USA is endometriosis, a condition afflicting 5.5% of American women. Exposure to excessive estrogen, that may have come from such sunscreens, is felt to be the primary cause of endometriosis. Perhaps a sunscreen using zinc oxide is a better choice.
Plastics chemical (Bisphenol A) harms eggs in unborn mice
Female mice exposed to a common chemical found in plastics while in the womb develop abnormal eggs, according to a new study. Based on this finding, researchers speculate that the chemical, bisphenol A, might increase the risk of spontaneous abortion and genetic disorders in humans, such as Down’s syndrome.
Bisphenol A, or BPA, is commonly found in hard plastics and the lining of tin cans. The chemical has come under scrutiny before because it can mimic the hormone oestrogen.
Patricia Hunt at Washington State University in Pullman, US, and colleagues exposed pregnant mice to 20 micrograms of BPA per kilogram of their bodyweight each day over a one-week period. During this same period, the reproductive cells of female mice developing inside in the womb begin a process of division known as meiosis.
Pthalates in Air Fresheners cause Hormone disruption
Studies involving rat and human subjects have suggested that high exposures to certain kinds of phthalates can cause cancer, developmental and sex-hormone abnormalities (including decreased testosterone and sperm levels and malformed sex organs) in infants, and can affect fertility. [Can this also cause breast cysts or a breast cyst?] The U.S. Food and Drug Administration has no regulations on the use of phthalates, does not require the labeling of phthalate content on products and does not consider the quantities to which people are exposed to be harmful. But other countries think otherwise. In 2004, the European Union banned two types of phthalates in cosmetics and also bans the chemical in children’s toys, as do 14 other countries. The first state bill to ban phthalates in children’s toys in the U.S. is currently sitting on California governor Arnold Schwarzenegger’s desk, and he is expected to sign it this week.
Are Phthalates In Baby Lotions, Powders And Shampoos Harmful?
Baby shampoos, lotions and powders may expose infants to chemicals that have been linked with possible reproductive problems, a small study suggests.
The chemicals, called phthalates, are found in many ordinary products including cosmetics, toys, vinyl flooring and medical supplies. They are used to stabilize fragrances and make plastics flexible.
In the study, they were found in elevated levels in the urine of babies who’d been recently shampooed, powdered or lotioned with baby products.
Trace Pharmaceuticals in Drinking Water Implicated in Intersex Fish
• In a broad study still under way, fish collected in waterways near or in Chicago, Illinois; West Chester, Pennsylvania; Orlando, Florida; Dallas, Texas; and Phoenix, Arizona, have tested positive for an array of pharmaceuticals — analgesics, antibiotics, antidepressants, antihistamines, anti-hypertension drugs and anti-seizure medications.
• That research follows a 2003 study in northern Texas, where every bluegill, black crappie and channel catfish researchers caught living downstream of a wastewater treatment plant tested positive for the active ingredients in two widely used antidepressants — one of the first times the residues of such prescription drugs were detected in wildlife.
• In several recent studies of soil fertilized with livestock manure or with the sludge product from wastewater treatment plants, American scientists found earthworms had accumulated those same compounds, while vegetables — including corn, lettuce and potatoes — had absorbed antibiotics. “These results raise potential human health concerns,” wrote researchers.
• Blood and liver samples of bull sharks in Florida’s Caloosahatchee River, a nursery area for juvenile bullsharks and home to six wastewater treatment plants, are being tested for the presence of an array of medications this winter. Of the first ten sharks sampled, nine tested positive for the active ingredient in an antidepressant.
• And in Colorado’s Boulder Creek, 50 of the 60 white suckers collected downstream of Boulder’s wastewater treatment plant were female, compared to about half of them upstream.
Elsewhere in the world — from the icy streams of England to the wild game reserves of South Africa — snails, fish, even antelope, are showing signs of possible pharmaceutical contamination. For example, fish and prawn in China exposed to treated wastewater had shortened life spans, Pacific oysters off the coast of Singapore had inhibited growth, and in Norway, Atlantic salmon exposed to levels of estrogen similar to those found in the North Sea had severe reproductive problems.
From a strictly research point of view there may not be enough evidence to create public outrage and shift public opinion. It is a known medical fact that estrogen stimulates breast cancer. However, it is disconcerting to note that the breast cancer rate is now 1 out of 8 women where before breast cancer in the 1950’s was 1 out of 20. Dr. Lee believes that overdose of estrogen either by pill or by xenoestrogens is the cause of Breast Cysts. The Pharmaceutical industry also believes this as they sell a drug specifically made to block the estrogen receptor selling this as a breast cyst cure. So what do we do?
- Use glass or ceramics whenever possible to store food and water. Heat up your food using a glass or ceramic bowl covered with dish. When plastic is heated, it diffuses very rapidly into food.
- Use a simple detergent with less chemicals; Nature Clean is a good choice for both laundry detergent and dish washing detergent.
- Simple Soap is a safe choice for shampoo and a body soap.
- Use natural pest control not pesticides.
- Avoid Synthetic Chemicals – Healthy Living in a Toxic World by Cynthia Fincher PhD. is a good place to start.
- Don’t use herbicides; use a cup of salt in a gallon of vinegar.
- Buy hormone free meats to eat.
- Buy “Organic” produce, produce grown without pesticides, herbicides or synthetic fertilizer or hormones.
- Use Condoms without spermicide for Birth control instead of Birth Control Pills. Use Natural Progesterone instead of HRT.
- In general, the hormones taken orally are first pass metabolized by the liver 80%-90%. However, when these hormones are applied to the skin, the hormones are directly absorbed by the body. Thus, any skin dose is 10 times that of an oral dose. The vast majority of skin lotions and creams use the parabens as a preservative. Avoid them at all costs. Instead apply a vegetable oil right after a shower to hydrate the skin and lock in the moisture.
The very important changes to make are do NOT eat food with HOT plastic. Change your laundry detergent, no fabric softener, change your lotions, soaps, shampoos, and makeup. Avoid Coffee.
Vendors: Living Source (254) 776-4878 for Nature Clean powdered laundry detergent, Conti Castile Soap 1-800-809-0610.
(The credit for the information is due to nobreastcyst.com/xeno.html)
Plastic Chemicals Could Be Cause Of Reproductive, Weight Problems, MU Researchers Say
ScienceDaily (Oct. 21, 1999) — COLUMBIA, Mo. – Over the past decades, researchers have reported a dramatic increase in the number of overweight Americans, reproductive deformities and the number of youth reaching puberty at early ages. In the past, these findings have been attributed to nutrition, lifestyle and genetics. However, in an article to be published in Nature this week, a team of researchers from the University of Missouri-Columbia and North Carolina State University report that a chemical estrogen that is used to make plastics could be a contributing factor.
The researchers, Kembra Howdeshell, an MU doctoral candidate; and Frederick vom Saal, MU professor of biological sciences; exposed mice to bisphenol A (BPA), similar to levels at which humans are routinely exposed. BPA is a compound that was originally made as a chemical estrogen, but that is now used as a “building block” for the production of polycarbonate plastic products such as baby bottles, tin can linings, certain toys and certain types of food storage containers. What resulted were findings that included an earlier onset of puberty and an increase in body weight after birth. Howdeshell and vom Saal also found that mice with more natural estrogen in them were much more sensitive to the chemical than those with low levels of natural estrogen.
“People sometimes get confused if 100 percent of the population doesn’t exhibit the exact same symptoms to a chemical, but there are varying effects in the animal as well as human population,” Howdeshell said. “That’s to be expected, but there is no way to predict natural levels of estrogens in humans without doing several series of invasive tests. The whole idea of government regulation is to protect the most sensitive subpopulation, which our findings identify as having the highest levels of natural estrogen.”
The study was conducted by exposing mice to BPA while still in the womb. Exposure was done just during pregnancy, not after birth. However, the study concluded that exposure to the chemical while still in the womb programs post-natal growth. On average, Howdeshell and vom Saal found that mice exposed to BPA weighed 20 percent more than normal when examined at puberty. The research was conducted over a period of one year and was funded by a $500,000 grant from the National Institutes of Health.
“We found that the largest effects happened to the babies of the pregnant mother,” Howdeshell said. “The chemical did not affect the mother, but instead it altered the babies’ growth patterns and accelerated timing of sexual maturity. Our study shows that this chemical may be a factor for contributing to trends seen in human populations over the past several decades.”
The researchers’ findings indicated that more work is needed to discover the exact effects of BPA on humans. However, in previous research, when both humans and mice were exposed to the same relative dose of chemical estrogens, the effects were nearly identical. Both experienced similar types of abnormalities of the reproductive system. This points to the need for research on humans.
“We’re not offering an answer concerning effects in humans with these findings; instead, the findings pose a question regarding human health,” vom Saal said. “This study should serve as a guide for human research. We believe that the medical community should take a long look at this study and consider looking at BPA as a possible cause for the changes in growth, sexual maturation and reproductive abnormalities that have been reported in the humans in the past decades.”
Vom Saal also has pointed out that food containers are not the only source of exposure to this chemical. BPA also is used to make computers, toys and other household items. Products made with BPA have been claimed to be nondegradable. However, at the Estrogens in the Environment conference in New Orleans Oct. 18-21, Howdeshell and vom Saal are presenting evidence from another study showing that BPA leaches out into the environment from plastic products with repeated use.